programas cribado cancer

Nota bibliográfica cribado c mama 2014-03

Kalager M, Løberg M, Bretthauer M, Adami H-O. Comparative analysis of breast cancer mortality following mammography screening in Denmark and Norway. Ann Oncol. 2014; Available from: doi: 10.1093/annonc/mdu122.

Conclusions The seemingly larger effect of screening in Denmark may not be solely attributable to screening itself, but to increased mortality in women older than 59 years not invited to screening.

Olsson Å, Sartor H, Borgquist S, Zackrisson S, Manjer J. Breast density and mode of detection in relation to breast cancer specific survival: a cohort study. BMC Cancer. 2014;14(1):229. Available from: doi: 10.1186/1471-2407-14-229.

CONCLUSIONS: High breast density at diagnosis may be associated with decreased breast cancer survival. This association appears to be stronger in women with symptomatic cancers but breast density could not explain differences in survival according to detection mode.

Bernardi D, Caumo F, Macaskill P, Ciatto S, Pellegrini M, Brunelli S, et al. Effect of integrating 3D-mammography (digital breast tomosynthesis) with 2D-mammography on radiologists’ true-positive and false-positive detection in a population breast screening trial. Eur J Cancer. 2014;50(7):1232–8. Available from: doi:10.1016/j.ejca.2014.02.004. PMID: 24582915.

CONCLUSION: There was broad variability in radiologist-specific TP detection at 2D-mammography and hence in the additional TP detection and incremental CDR attributable to integrated 2D/3D-mammography; more consistent (less variable) TP-detection estimates were observed for the integrated screen-read. Integrating 3D-mammography with 2D-mammography improves radiologists’ screen-reading through improved cancer detection and/or reduced FPR, with most readers achieving both using integrated 2D/3D mammography.

Gérvas J, Fernández MP. Sobrediagnóstico, un problema clínico, ético y social. FMC - Form Médica Contin en Atención Primaria. 2014;21(3):137–42. Available from: doi: 10.1016/S1134-2072(14)70724-8
Duffy SW, Michalopoulos D, Sebuødegård S, Hofvind S. Trends in aggregate cancer incidence rates in relation to screening and possible overdiagnosis: A word of caution. J Med Screen. 2014;21(1):24–9. Available from: doi: 10.1177/0969141313517676.

Conclusion There are potential errors in estimation of overdiagnosis from screening if individual data on screening exposure and detection mode are not taken into account. For reliable estimates of overdiagnosis, it is necessary to compare excess incidence in the screening period in those actually screened with the corresponding excess in those not screened. This is the subject of ongoing research
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